Nicholas Saputra rose to fame as Rangga in the film Ada Apa dengan Cinta? (AADC). The film, which was produced by Mira Lesmana and Riri Riza, was his debut as a film actor. Several films Biola Tak Berdawai (2003), Janji Joni (2005), 3 Hari untuk Selamanya (2007), Drupadi (2008), Sarinah (2011), and Cinta dari Wamena (2013).
His acting success is marked by the various awards he has won. One of them was the Citra Trophy for the Best Supporting Actor category at the prestigious Indonesian Film Festival through Arjuna & Lidahnya.
Nicholas Saputra has also tried to work behind the scenes by becoming a producer for a documentary film titled SEMESTA. The film was released on January 30, 2020.